Sex Made Obsolete, Mouse Stem Cells Used To Make Eggs Resulting In New Healthy Mice That Can Reproduce

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Scientists in Japan report they have created eggs from stem cells in a mammal for the first time. And the researchers went on to breed healthy offspring from the eggs they created.


Credit: Katsuhiko Hayashi

A research group of Associate Prof Katsuhiko Hayashi and Professor Saito, Graduate School of Medicine, used pluripotent stem cells from mice to successfully fabricated the eggs for the procreation of mice from the eggs. The research group, which had been successful in making sperm cells from male stem cells, have now produced eggs from stem cells for the first time. The eggs were fertilized and have produced baby mice which on reaching maturity can procreate.

Associate Professor Hayashi, Professor Saito from leftCredit: Katsuhiko Hayashi

The research group this time, from which to make sperm and egg cells iPS cells and ES of female mouse primordial germ cell. After incubation they transplanted the fertilized eggs int female mice where they wereallowed to mature and were born from the females in whch they had been transplated. They got a healthy mkce throughin vitro fertilization.They also found that these mice grow normally, have the ability to make a child.

　It is expected the research will contribute to the elucidation of the mechanism by which the the egg will be formed. It is also expected the technology will also help determine the cause of infertility.　

The results of this research have been published in “Science express” an online bulletin of the magazine Science in United States (U.S. Eastern Time),on October 04, 2012.

Point of the study
ES cells of mouse eggs produced from iPS cells
Successfully obtained by in vitro fertilization healthy mouse made from egg
Contribution mechanisms of egg formation, and determine the cause of infertility

Offspring obtained by in vitro fertilization of eggs and their derived PGCLCs that Figure 2 ES cells differentiated from

Credit: Katsuhiko Hayashi


Offspring obtained by in vitro fertilization of eggs and their derived PGCLCs that were differentiated from Figure 3 iPS cells

Credit: Katsuhiko Hayashi

Background and history of research (This portion has been translated from Japanese by Google and has not yet been corrected for good english grammer. Please check back later.)

Source: Katsuhiko Hayashi
 
Citation: “Offspring from oocytes in vitro Derived from Primordial Germ Cell-Like Cells in Mice”
(successful production from mouse oocytes derived from primordial germ cells obtained in vitro culture)

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